Our research focuses on the use of sophisticated imaging and processing techniques to probe metabolic and biochemical features of human tissues. Some of the techniques we use include:
Magnetic Resonance Imaging (MRI)
MR imaging techniques are available for researchers requiring high-resolution imaging of joints and soft tissues. We have expertise in design and implementation of imaging protocols, as well as close supervision during data acquisition.
We work closely with investigators in order to modify or develop MRI acquisition protocols that address specific clinical endpoints. These methods include:
- cartilage relaxometry measures using T2, T2* and T1rho
- high-resolution cartilage imaging for 3D modeling and simulations
- high-resolution bone imaging for 3D reconstructions
Magnetic Resonance Spectroscopy (MRS)
1H-MRS allows non-invasive quantification of muscle metabolites, such as lipids, total creatine, and choline. Using this methodology, we’re capable of differentiating and selectively measuring lipids located inside or in between muscle cells. This technique has been widely employed in studies investigating mechanisms of insulin sensitivity in type 2 diabetics, obese and HIV-lipodystrophy patients.
We acquire 1H-MRS data using GE and Siemens scanners at 1.5T or 3.0T field strengths, and perform analyses with softwares such as LCModel, iNMR and jMRUI.
We can modify or develop MRS acquisition protocols in order to address your specific clinical endpoint.
Quantitative Computed Tomography (QCT)
QCT is a powerful method for assessment of body composition and bone mineral density (BMD).
Using a single slice of the abdomen obtained at L4, a variety of adipose tissue compartments can be measured while keeping radiation exposure to a minimum. Standard measurements obtained using dedicated software include:
- Intra-abdominal (visceral) fat area
- Subcutaneous fat area
- Total adipose tissue area
- Total cross-sectional area
Bone mineral density
QCT is widely employed for determination of bone mineral density (BMD) of the lumbar spine. This methodology bypasses certain limitations of DXA planar acquisitions, and allows reliable estimates of BMD. We obtain CT slices at 4 lumbar levels and measure vertebral body density calibrated by a standard phantom.
We can modify or develop QCT protocols and measurement methodology in order to address your specific clinical endpoint.
If you have any questions about metabolic imaging techniques, please contact us.