Monthly Archives: January 2014

Brown adipose tissue has a positive effect on bone


Quantification of brown adipose tissue (BAT) within red region of interest. BAT in the supraclavicular region shows as dark nodular areas of increased activity in PET (Panel A) that correspond to orange areas in fused PET/CT (Panel B).

Investigators from our group, including Miriam Bredella and Corey Gill, performed a study in adults that measured brown adipose tissue (BAT) by 18F-FDG positron emission tomography/computed tomography and found it is a positive predictor of femoral bone structure, correlating with thigh muscle and subcutaneous fat.

This work expands that by Ponrartana et al., who found a similar positive relationship between BAT volume and bone cross sectional area in children. Given that the pediatric population is more likely to have higher quantities of BAT, our work suggests this positive relationship between BAT and bone also remains influential in adults.